The Landmark London was originally opened by the Great Central Railway, as the Hotel Great Central. It is a five star hotel on Marylebone Road on the northern side of central London, England in the borough of London named the City of Westminster. The hotel was a Victorian era hotel and the architect who built it was Colonel Sir Robert William Edis and the style was eclectic and luxurious. The hotel was used as a military office building during the world war and also after that for some more years.

The hotel was reopened under the name the Regent after the demand for more hotels became more in the late 20th century. In 1995, it was purchased by the Lancaster Landmark Hotel Company Limited from its Japanese owners and was renamed as The Landmark London. The Landmark is a Thai company and owns many hotels in London. The Landmark London hotel has now has 300 rooms and suites.